tert-Butyl nitrite S-Nitroso compounds (thionitrites): LA810.Isobutyl nitrite (2-methylpropyl nitrite).Nitroso compounds/ nitrites: Nitrite (NO −Ģ) O-Nitroso compounds ( alkyl nitrites): Amyl nitrite (isoamyl nitrite, isopentyl nitrite).Nitroglycerin (glyceryl trinitrate (GTN)).Naproxcinod (nitronaproxen AZD-3582, HCT-3012).Ethylene glycol dinitrate (EGDN nitroglycol).Nitrates: Diethylene glycol dinitrate (DEGDN).^ a b c d e f g h i "Monoket- isosorbide mononitrate tablet".^ "Isosorbide - Drug Usage Statistics".^ a b British national formulary : BNF 76 (76 ed.).American Society of Health-System Pharmacists. ^ a b c d e f "Isosorbide Dinitrate/Mononitrate Monograph for Professionals".^ "Isosorbide mononitrate Use During Pregnancy".In Australia, this drug is available under the brand name Duride. In Russia it is occasionally used under the brand names Monocinque and Pektrol. In India, this drug is available under the brand names of Ismo, Imdur, Isonorm, Monotrate, Solotrate, and Monit. It is sold in the US by Lannett Company, under the trade name Monoket, and was also sold in the US under the name Imdur, and marketed in the UK under the trade names: Isotard, Monosorb, Chemydur.
Dose adjustments of either class of agent may be necessary. Marked symptomatic orthostatic hypotension has been reported when calcium antagonists and organic nitrates were used in combination. The additional effect of isosorbide mononitrate was especially evident in patients whose portal pressure was not reduced by propranolol. The addition of isosorbide mononitrate to propranolol treatment in patients with cirrhosis and portal hypertension caused a marked fall in portal pressure, a reduction in hepatic blood flow, cardiac output and mean arterial blood pressure, but no additional change in azygos blood flow.
The addition of a calcium channel blocker of the verapamil type, such as gallopamil 75 mg, has been shown to further improve left ventricular functional parameters when given in combination with isosorbide mononitrate in a sustained-release formulation. Concomitant administration of other exogenous sources of sulfhydryl groups such as methionine and captopril may produce a similar interaction. The combination of oral N-acetylcysteine and a single dose of sustained-release isosorbide mononitrate 60 mg significantly prolonged the total exercise time in patients with angina pectoris and angiographically proven significant coronary artery disease, when compared with isosorbide mononitrate alone. The metabolism of organic nitrates to nitric oxide is dependent on the presence of sulfhydryl groups in the muscle. Therefore, sildenafil should not be given to patients already receiving isosorbide mononitrate therapy. Life-threatening hypotension may also occur. Concomitant administration of isosorbide mononitrate and sildenafil (Viagra) or other phosphodiesterase inhibitors (Tadalafil and Udenafil) can potentiate the vasodilatory effect of isosorbide mononitrate with the potential result of serious side-effects such as syncope or myocardial infarction. Other reactions that have been reported with isosorbide mononitrate-modified release tablets include tachycardia, vomiting, diarrhoea, vertigo, and heartburn. In general, these symptoms disappear during long-term treatment. Hypotension (4%) with symptoms such as dizziness and nausea (1%) have been reported. They occur mainly in the early stages of treatment. Hypotension (4 to 5%), poor appetite (2.5%), nausea (1%) Īdverse effects associated with the clinical use of the drug are as expected with all nitrate preparations. Ĭommon: Tiredness, sleep disturbances (6%) and gastrointestinal disturbances (6%) have been reported during clinical trials with isosorbide mononitrate modified-release tablets, but at a frequency no greater than for placebo. Very common: Headache predominates (up to 30%) necessitating withdrawal of 2 to 3% of patients, but the incidence reduces rapidly as treatment continues. The following adverse effects have been reported in studies with isosorbide mononitrate: The oral, slow release tablet has an onset of thirty minutes, and a duration of 8 hours.
MONIT GTN 2.6 USED PATCH
The sublingual patch has an onset of five minutes and a duration of action of one hour. Isosorbide mononitrate is a nitrate-class drug used for the prevention of angina pectoris.